This webinar will be comprised of 5 short presentations from the Superfund Research Program Individual Research Grants (R01).
The NIEHS Superfund Research Program (SRP) released a funding opportunity announcement in 2010 titled RFA ES-11-005 "Innovative Bioavailability Assays to Assess the Effectiveness of Contaminated Sediment Remediation (R01)." This solicitation called for the development of innovative assays of bioavailability that may be used to determine the effectiveness of sediment remediation in reducing risks to humans. The ultimate goals of this solicitation are two-fold: first, to develop and introduce new tools to assess whether remediation efforts are protective of human health; and second, to increase use of bioavailability in risk assessment through providing scientifically-valid, practical, and cost-effective tools. In response to this solicitation, five three-year awards were made in 2011.
HALDEN, ROLF U.
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
In Situ Sampling Tool for Assessing Bioavailability and Toxicity of Sediments
Dr. Halden's in situ sampling/bioavailability determination (IS2B) tool simultaneously determines levels of contaminants in bulk water and pore water at low method detection limits. They will utilize a DNA microarray technology as a biological response to chemical readings measured by the IS2B in Lake Apopka and will study emerging contaminants (triclosan, triclocarban, fipronil) along with historical contaminants (ppDDE, dieldrin). This is a Multi-PI grant including both Dr. Rolf Halden and Dr. Nancy Denslow (University of Florida).
RANVILLE, JAMES
COLORADO SCHOOL OF MINES
Remediation Effectiveness for Mining Sites: Hysteresis and Metal Mixtures Effect
Dr. Ranville proposes to further develop a ÒgellyfishÓ assay technology that targets metal ion speciation, is capable of multiplexing (Cd, Pb, Cu, and Zn) and integrates into fate and transport models (mixed metal, multi-site biotic ligand model [MMMS BLM]) allowing an estimate of metals that link to human exposure risks. Lab and field (Clear Creek, CO Superfund Site) studies will indicate if metal remediation effectively removes the toxic metals without affecting essential metals that mitigate toxicity.
GAN, JAY
UNIVERSITY OF CALIFORNIA RIVERSIDE
Development of Stable Isotope Based Methods to Predict Bioavailability of Hydrophobic Organic Contaminants in Sediments
Dr. Gan uses stable isotope labeled hydrophobic organic contaminants (HOCs) to advance capabilities to measure (ex situ or in situ) bioavailability of HOCs in sediments. This project potentially expands the applicability of a promising passive sampling bioavailability tool (solid-phase microextraction [SPME] samplers) to use in non-equilibrium conditions. The project will assess PAHs, PCBs, DDT, and DDE and involves work at the Palos Verdes Shelf Superfund Site undergoing capping.
GHOSH, UPAL
UNIVERSITY OF MARYLAND BALTIMORE COUNTY CAMPUS
Combining bioavailability assays with modeling to predict PCBs in fish after remediation
Dr. Ghosh aims to provide mechanistic insight into the use of passive sampling devices (PSDs), which are commonly used to assess pore water concentrations of contaminants. This research will use advanced technologies to directly measure the diffusion of organic molecules in commonly used passive sampler materials (polyethylene, polyoxymethylene, and poly(dimethylsiloxane)/PDMS). Investigators will work at the Grasse River, NY Superfund Site undergoing remediation for polychlorinated biphenyls (PCBs).
UNGER, MICHAEL
VIRGINIA INSTITUTE OF MARINE SCIENCE
A real-time antibody-based field assay to predict containment bioavailability in sediments
Dr. Unger will calibrate and apply an automated monoclonal antibody-based sensor to quantify and characterize compositional characteristics of polycyclic aromatic hydrocarbons (PAHs) in aqueous and sediment pore water as a surrogate measure of chemical bioavailability in oysters. This sensor, which permits simultaneous monitoring of different PAH classes within a single site, will be deployed at the Elizabeth River, VA Superfund Site undergoing dredging and capping remediation. This is a Multi-PI grant including Dr. Michael Unger, Dr. Stephen Kaattari, and Dr. Wolfgang Vogelbein (VIMS).
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