ITRC PFAS Beyond the Basics: PFAS Human Health, Ecological Effects and Regulations Training

This training class builds on the earlier information for introductory PFAS topics presented in the PFAS 101 CLU-IN training. It provides more in-depth information for human health effects, ecological toxicity and ecological risk assessment, PFAS regulations, and AFFF alternatives and replacement.

Resources and further details for the topics included in this training are in the published PFAS-1 guidance document in Sections 7, 8 and 17.2 along with referenced tables.

Learning Objectives:

• Discuss new information on the health effects of categories of PFAS not previously addressed. We'll also talk about the recent use of data from epidemiology studies to develop toxicity factors and guidelines; describe how the U.S. EPA has recently used a mixtures approach to derive a proposed MCL for 4 PFAS. We'll discuss why certain agencies are regulating PFAS as a class, and give examples, and will also give brief updates on our understanding of the adverse effects of PFAS after inhalation or dermal exposure.
• Discuss PFAS exposure pathways relevant to ecological receptors; general toxicological information available for invertebrates, vertebrates, and plants; the data gaps and uncertainties associated with ecotoxicological studies; and current approaches in ecological risk assessment of PFAS.
• Discuss development and findings of some of the External Data Tables including the Water and Soil Values Table, the Air Criteria Table, and the Regulatory Programs Summary Table. Discuss the current status of some of the Federal Regulations including drinking water regulations and how this may impact some states. Discuss the current status of AFFF alternatives and replacement.

Linda Hall, Linda C. Hall (Lindachall@comcast.net)
Dr. Hall is an independent consulting toxicologist based in the California Bay Area.  She has over 30 years of experience in environmental toxicology and human health risk assessment. Dr. Hall has actively followed the emerging science of per and polyfluoroalkyl substances (PFAS) toxicology, and is in her eighth year with the Interstate Technology and Regulatory Council (ITRC) PFAS team.  She previously served as co-leader of the Regulations, Toxicity, and Risk Assessment group of ITRC, and now co-leads the Human and Ecological Effects subgroup.  Dr. Hall has been a Principal Investigator (PI) and co-PI for EPA-, California-, and Department of Energy-funded research while at the University of California and Lawrence Livermore National Laboratory. She holds a Masters degree in Toxicology and a Ph.D. in Ecology (Ecological Toxicology).

Kristi Herzer, Vermont Department of Environmental Conservation (kristi.herzer@vermont.gov)
Kristi Herzer is an Environmental Analyst and Technical Program Lead for the State of Vermont's Department of Environmental Conservation. Kristi is a project manager in the Brownfields Program and the Sites Management Section and promotes the Vermont Brownfields Reuse and Environmental Liability Limitation Act (BRELLA) program. Kristi is the Division representative on VTDEC's Environmental Justice Team, an active member in a cross-agency PFAS workgroup, and co-author of multiple internal and external guidance documents for the regulated community. Since 2017, Kristi has served as a member and subgroup leader for the Sampling and Analysis section of ITRC's PFAS team, and most recently also serves as a subgroup leader of the PFAS Training team. Kristi holds a Bachelor of Science in Physics and Biology from Guilford College and a Master's Degree in Environmental Engineering from the University of Vermont.

Chris McCarthy, M.S., Jacobs (chris.mccarthy@jacobs.com)
Chris McCarthy, M.S. is a nationally recognized ecological risk assessment expert with 24 years of experience. Chris has led risk assessments at sites around the U.S., Australia, Canada, and France. He directs teams in evaluating the likelihood and magnitude of adverse effects to human and non-human biota exposed to contaminants at hazardous waste sites and working with engineers on risk management strategies. Chris has been actively engaged in the thought leadership for PFAS ecotoxicity related work, leading toxicity studies with PFAS, and leading PFAS risk assessments at sites through the US and Australia. Chris regularly presents updates and gives training on the ecotoxicity and risk assessment of PFAS to audiences around the world. Chris is also an active member of the ITRC PFAS team including the regulations, toxicity, risk assessment, and surface water criteria subgroups. Chris earned a BS in Water Resources Management from University of New Hampshire and an M.S. in Biology from Minnesota State University.

Lisa McIntosh, Terraphase (lisa.mcintosh@terraphase.com)
Lisa McIntosh is a Principal Toxicologist and Risk Assessment Consultant at Terraphase Engineering. Ms. McIntosh has over two decades of expertise in conducting both human health and ecological risk assessments, with additional experience in risk communication, environmental site assessment, wetland science and ecological restoration. Ms. McIntosh is certified as a general toxicologist by the American Board of Toxicology. She is actively involved in the scientific and regulatory community, including the Society of Environmental Toxicology and Chemistry, Society for Women Environmental Professionals and the Interstate Technology and Regulatory Council PFAS workgroup.

Brie Sterling, PA DEP (Bsterling@pa.gov)
Brie Sterling is an Environmental Group Manager with the Pennsylvania Department of Environmental Protection’s (PADEP) Land Recycling Program (Act 2) in Harrisburg, PA. Brie has been with PADEP since 2008 and currently leads the Remediation Standards Section, which provides technical support for risk assessment, vapor intrusion, and other project-related matters in support of the PADEP regional offices. Brie's group also maintains the toxicity database and the MSC calculations for the regulations and provides technical support for the regions regarding the Chapter 250 regulations. Brie also serves as a writing group co-lead on ITRC's PFAS team since its inception in 2017. Prior to joining the Remediation Standards section in 2012, Brie worked at the DEP BOL as an analytical chemist following a number of years in the analytical chemistry field at various environmental and industrial labs.

Shalene Thomas, Batelle (thomass3@battelle.org)
Shalene Thomas is the Senior Emerging Contaminant Program Manager for Battelle. She has more than 25 years of experience in environmental consulting and has supported State, Federal and industrial clients with emerging contaminants risk management and mitigation strategies. She has supported emerging contaminants projects in 32 different states in 9 of the 10 USEPA regions as well as in Europe, Australia and Canada and has presented on the topic of PFAS and trained professionals in emerging contaminants across the US, Canada, and Australia.

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ITRC Training Program (itrc@itrcweb.org)

• Slide Presentation for ITRC BTB - Human Health & Ecological Effects (4.10MB/PDF)

Webinar Slides and References:

• Slide Presentation for ITRC BTB - Human Health & Ecological Effects (4.10MB/PDF)

Additional Resources:

• These materials will be available by

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