U.S. EPA Contaminated Site Cleanup Information (CLU-IN)

U.S. Environmental Protection Agency
U.S. EPA Technology Innovation and Field Services Division

Dense Nonaqueous Phase Liquids (DNAPLs)


Halogenated Alkanes


Human Health Toxicity

1,1,2-Trichloro-1,2,2-trifluoroethane, also known as TCTFE, Freon 113, and CFC-113, had wide use as an industrial solvent, refrigerant, and feedstock in the production of other chemicals. Production of CFC-133 is now banned, and consequently, emissions are declining. Domestic use of a contaminated water supply might expose the user via ingestion, or via inhalation when the compound volatilizes from water used for cooking, bathing, or showering. Dermal contact with CFC-113 can occur when bathing or showering (Lewis 1997).

Results from tests involving human volunteers have shown that over half the inhaled dose of CFC-113 is exhaled immediately, with very little being absorbed and appearing in urine. Animal studies indicate that when exposure to CFC-113 ceases, any compound that had passed to the tissues is released into venous blood. CFC-113 does not appear to be metabolized by either humans or experimental animals (Lewis 1997).

CFC-113 is of low toxicity to humans and laboratory animals. Results from an inhalation study on human volunteers suggest that high levels of CFC-133 can cause drowsiness, loss of concentration, and dizziness; however, these effects were reported to be temporary, with resolution within 15 minutes of cessation of exposure (Lewis 1997).

A chronic toxicity study employing rats did not suggest that CFC-113 is carcinogenic; however, an increase in liver weight in male rats was reported in all groups (Lewis 1997).

The offspring of rodents exposed to CFC-113 in pregnancy did not develop abnormalities of the soft tissues or skeleton (Lewis 1997).

CFC-113 gave negative results in the Ames Salmonella genotoxicity assay, and did not show mutagenic activity in an in vivo mouse genotoxicity test (Lewis 1997).


Public Health Goal for 1,1,2-Trichloro-1,2,2-trifluoroethne in Drinking Water Adobe PDF Logo
Lewis, D.
California EPA, Office of Environmental Heath Hazard Assessment, 21 pp, 1997

For Further Information

1,1,2-Trichloro-1,2,2-trifluoroethane (CASRN 76-13-1)
U.S. EPA, Integrated Risk Information System (IRIS).

Ecological Toxicity

No data were found that describe the ecotoxicity of CFC-113.

Other DNAPLs Toxicology Topics: